VERAPAMIL HYDROCHLORIDE Tablet [A-S Medication Solutions]
General
Use within patients with impaired hepatic function: Since verapamil is extremely metabolized through the liver, it ought to be administered very carefully to patients with impaired hepatic function. Severe liver disorder prolongs the elimination half-existence of verapamil to around 14 to 16 hrs hence, roughly 30% from the dose provided to patients with normal liver function ought to be administered to those patients. Careful monitoring for abnormal prolongation from the PR interval or any other indications of excessive pharmacologic effects (see OVERDOSAGE ) ought to be transported out.
Use within patients with attenuated (decreased) neuromuscular transmission: It’s been reported that verapamil decreases neuromuscular transmission in patients with Duchenne’s muscular dystrophy, which verapamil prolongs recovery in the neuromuscular blocking agent vecuronium,…